产品名称：CDDO Imidazolide
同义名称：1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole; 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid imidazolide; CDDO-Im; RTA 403; TP 235;
CAS 号:443104-02-7
分子式：C₃₄H₄₃N₃O₃
性状:Pale Yellow to Very Dark Yellow Solid
熔点:>164°C (dec.)
分子量：541.72
存储:-20°C
溶解度:Chloroform (Slightly), Methanol (Very Slightly, Heated)
Stability
Light Sensitive
产品类别：Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
产品应用：CDDO Imidozolide (CDDO-Im) is a synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. Studies show that CDDO-Im is highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines as well as being an effective therapeutic agent in the treatment of other types of cancers.
参考文献:Hughes, D.T. et al.: Cancer Invest., 26, 118 (2008); Place, A.E. et al.: Clin. Cancer Res., 9, 2798 (2003); Samudio, I. et al.: J. Biol. Chem., 280, 36273 (2005);
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